Anti-Islet Cell (ICA) Antibody ELISA Kit

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Cov khoom siv no yog tsim los rau qhov zoo hauv vitro nrhiav pom ntawm cov tshuaj tiv thaiv islet cell antibody (ICA) qib hauv tib neeg cov ntshav. Clinically, nws yog siv los ua ib qho cuab yeej pab kuaj mob rau Hom 1 Mob ntshav qab zib mellitus (T1DM).

Islet cell antibodies yog autoantibodies uas tsom cov antigens ntawm qhov chaw lossis hauv cov kab mob pancreatic, tshwj xeeb tshaj yog β hlwb. Lawv lub xub ntiag yog cuam tshuam nrog autoimmune kev puas tsuaj rau cov islet hlwb, uas yog ib qho tseem ceeb pathological feature ntawm T1DM. Nyob rau theem pib ntawm T1DM, txawm tias ua ntej pom tseeb cov tsos mob xws li hyperglycemia tshwm sim, ICA feem ntau tuaj yeem kuaj pom hauv cov ntshav, ua rau nws yog ib qho tseem ceeb ntawm kev tiv thaiv kab mob thaum ntxov.

Rau cov tib neeg uas muaj keeb kwm mob ntshav qab zib hauv tsev neeg lossis cov uas pom cov tsos mob ua ntej ntshav qab zib, kuaj ICA qib pab ntsuas qhov kev pheej hmoo ntawm kev tsim T1DM. Tsis tas li ntawd, hauv cov neeg mob uas tsis paub meej txog qhov ua rau hyperglycemia, ICA kuaj cov pab cuam hauv kev sib txawv T1DM los ntawm lwm hom ntshav qab zib, yog li qhia txog kev tsim cov phiaj xwm kho mob. Los ntawm kev saib xyuas cov kev hloov pauv hauv qib ICA, nws tseem tuaj yeem muab cov ntaub ntawv siv rau kev ntsuas kev loj hlob ntawm islet cell puas thiab kev ua tau zoo ntawm kev cuam tshuam kev ntsuas.

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Khoom cim npe

Txoj Cai

Cov khoom siv no kuaj pom cov islet cell antibodies (ICA) hauv tib neeg cov ntshav kuaj ntshav raws li txoj kev tsis ncaj, nrog rau cov islet cell antigens purified siv los ua cov txheej txheem antigen.

Cov txheej txheem kev sim pib los ntawm kev ntxiv cov qauv ntshav rau cov tshuaj tiv thaiv qhov dej ua ntej coated nrog antigen, tom qab ntawd incubation. Yog tias ICA muaj nyob hauv cov qauv, nws yuav tshwj xeeb khi rau cov islet cell antigens hauv cov qhov dej, tsim cov antigen-antibody complexes ruaj khov. Cov khoom tsis sib xws raug muab tshem tawm los ntawm kev ntxuav kom ntseeg tau tias qhov tseeb ntawm cov tshuaj tiv thaiv tom ntej.

Tom qab ntawd, cov enzyme conjugates ntxiv rau hauv qhov dej. Tom qab qhov thib ob incubation kauj ruam, cov enzyme conjugates khi rau cov antigen-antibody complexes uas twb muaj lawm. Thaum TMB substrate tov yog qhia, lub enzyme nyob rau hauv lub complex catalyzes ib tug tshuaj tiv thaiv nrog TMB, uas ua rau ib tug pom kev hloov xim. Thaum kawg, tus nyeem ntawv microplate yog siv los ntsuas qhov nqus (A tus nqi), uas tso cai rau kev txiav txim siab ntawm ICA qib hauv cov qauv raws li qhov siv ntawm cov tshuaj tiv thaiv xim.

Khoom nta

High rhiab heev, tshwj xeeb thiab stability

Khoom Specification

Txoj Cai	Enzyme txuas immunosorbent assay
Hom	Tsis ncajTxoj kev
Daim ntawv pov thawj	NMPA
Cov qauv	Tib neeg cov ntshav / ntshav
Specification	48T / hli96T
Cia kub	2-8℃
Txee lub neej	12hli