Kev kuaj mob HFRS - Hemorrhagic Fever nrog rau lub raum Syndrome

Keeb kwm

Tus kab mob Hantaan (HV) yog thawj tus kab mob ua rau Hemorrhagic Fever with Renal Syndrome (HFRS). HFRS yog ib hom kab mob sib kis zoonotic mob kis thoob ntiaj teb uas ua npaws, ntshav, thiab raum tsis zoo. Tus kab mob muaj qhov pib mob hnyav, kev loj hlob sai, thiab muaj kev tuag ntau, ua rau muaj kev hem thawj rau pej xeem kev noj qab haus huv. Cov nas tsuag (xws li Apodemus agrarius thiab Rattus norvegicus) yog lub hauv paus reservoirs thiab vectors ntawm HV. Kev kis mus rau tib neeg feem ntau tshwm sim los ntawm aerosolized excreta ( tso zis, quav, qaub ncaug), tiv tauj ncaj qha, los yog vector tom. HFRS tuaj yeem tshwm sim thoob plaws hauv lub xyoo, thiab cov pej xeem feem ntau raug cuam tshuam. Raws li WHO txheeb cais, 32 lub teb chaws thoob ntiaj teb tau tshaj tawm cov kab mob HV, tshwj xeeb tshaj yog nyob rau sab hnub tuaj Asia, Europe, thiab Balkans.

Antibody Markers Post HV Kab Mob

Tom qab HV kab mob, tib neeg lub cev tiv thaiv kab mob tsim cov tshuaj tiv thaiv tshwj xeeb, feem ntau HV-IgM thiab HV-IgG.

● HV-IgM cov tshuaj tiv thaiv: Ua haujlwm ua tus cim cim ntawm kev kis kab mob thaum ntxov, feem ntau tshwm sim nyob rau hnub ntawm cov tsos mob tshwm sim, thiab tseem ceeb heev rau kev kuaj mob hnyav.

● HV-IgG cov tshuaj tiv thaiv: tshwm sim tom qab thiab tuaj yeem nyob mus ib txhis, qhia tias muaj kab mob yav dhau los lossis kev ua tsis tiav. Ib qho plaub-fold lossis ntau dua ntawm HV-IgG antibody titer ntawm cov qauv mob hnyav thiab cov kab mob convalescent kuj yog kuaj rau tus kab mob hnyav.

Hom HV Diagnostic Methods

Tam sim no txoj hauv kev kuaj HV muaj xws li kev cais tus kab mob, PCR, serological ELISA, thiab colloidal kub immunoassays.

● Kab lis kev cai kab lis kev cai thiab PCR muaj qhov tshwj xeeb tshaj plaws tab sis siv sijhawm ntev, kev xav tau, thiab xav tau cov chaw kuaj mob siab heev, txwv tsis pub siv dav.

● Micro-immunofluorescence (MIF) muaj qhov raug zoo tab sis yuav tsum muaj lub tshuab ntsuas fluorescence thiab cov kws tshaj lij txhais lus, txwv tsis pub siv cov ntawv thov niaj hnub.

● ELISA thiab colloidal kub kev soj ntsuam tau dav siv nyob rau hauv cov chaw kho mob vim lawv qhov yooj yim, ceev, siab rhiab heev thiab tshwj xeeb, thiab yooj yim ntawm cov qauv sau (cov ntshav / ntshav).

Product Performance

Beier Bio's HV-IgM/IgG (ELISA) Kev Ntsuas Cov Nta

● Hom Qauv: Ntshav, ntshav

● Sample Dilution: Ob qhov kev ntsuam xyuas IgM thiab IgG siv cov qauv zoo qub nrog 1:11 dilution (100µl qauv diluent + 10µl qauv), streamlining workflow thiab txo cov neeg ua haujlwm ua haujlwm.

● Reagent Npaj-rau-Siv: Tag nrho cov reagents npaj tau tshwj tsis yog ntxuav buffer (20 × concentrated). Xim-coded rau kev txheeb xyuas yooj yim

● Cov txheej txheem Incubation: 30 min / 30 min / 15 min; tag nrho automatable

● Kev Tshawb Nrhiav Wavelength: 450 nm nrog 630 nm siv

● Coated Strips: 96 los yog 48 lub qhov dej tawg, txhua tus muaj cov khoom lag luam luam tawm rau kev taug qab thiab yooj yim

Beier Bio's HV-IgM / IgG (Colloidal Kub) Kev Ntsuas Cov Nta

● Hom Qauv: Ntshav

● Lub Sij Hawm Tshawb Pom: Cov txiaj ntsig tau nyob hauv 15 feeb; tsis muaj khoom siv ntxiv; Qhov zoo tshaj plaws rau kev tshuaj ntsuam xyuas sai hauv cov neeg mob sab nraud, xwm txheej ceev, thiab cov neeg mob tawg ua ke

● Cov txheej txheem: Ntxiv 10µl qauv rau daim ntawv xeem daim qauv zoo siv lub dropper; txhais cov txiaj ntsig hauv 15-20 feeb

Clinical Performance of HV-IgM (ELISA), HV-IgG (ELISA), thiab HV-IgM/IgG (Colloidal Gold)