Mob Tes, Ko Taw, thiab Qhov ncauj (HFMD) Txheej txheem cej luam
Kab mob Tes, Ko Taw, thiab qhov ncauj feem ntau muaj nyob hauv cov menyuam yaus. Nws kis tau zoo heev, muaj feem ntau ntawm cov kab mob asymptomatic, txoj kev sib kis tau yooj yim, thiab kis tau sai, uas yuav ua rau muaj kev sib kis thoob plaws hauv lub sijhawm luv luv, ua rau muaj kev sib kis nyuaj. Thaum muaj kev sib kis, cov kab mob sib koom ua ke hauv cov tsev kawm qib kindergartens thiab cov chaw zov me nyuam, nrog rau kev sib koom ua ke ntawm tsev neeg, tuaj yeem tshwm sim. Xyoo 2008, HFMD tau suav nrog Ministry of Health hauv kev tswj hwm cov kab mob C.
Coxsackievirus A16 (CA16) thiab Enterovirus 71 (EV71) yog cov kab mob uas ua rau HFMD. Cov ntaub ntawv kab mob sib kis tau qhia tias CA16 feem ntau ncig nrog EV71, ua rau HFMD nquag tshwm sim. Thaum muaj cov kab mob sib kis no, qhov feem pua ntawm cov kab mob CA16 tshaj li ntawm EV71, feem ntau suav txog ntau dua 60% ntawm tag nrho cov kab mob. HFMD tshwm sim los ntawm EV71 tuaj yeem ua rau lub paj hlwb puas. Qhov feem pua ntawm cov neeg mob hnyav thiab cov neeg mob tuag taus ntawm cov neeg mob uas muaj EV71 muaj ntau dua li cov neeg muaj tus kab mob enteroviruses, nrog rau cov neeg mob hnyav tuag mus txog 10% -25%. Txawm li cas los xij, tus kab mob CA16 feem ntau tsis ua rau muaj ntau yam kab mob hauv nruab nrab ntawm lub paj hlwb xws li aseptic meningitis, brainstem encephalitis, thiab poliomyelitis-zoo li tuag tes tuag taw. Yog li ntawd, kev kuaj mob ntxov ntxov yog qhov tseem ceeb tshwj xeeb rau kev cawm lub neej ntawm cov mob hnyav.
Kev kuaj mob
Kev kuaj mob tam sim no rau HFMD feem ntau suav nrog kev kuaj pom nucleic acid ntawm cov kab mob thiab kuaj cov tshuaj tiv thaiv kab mob. Lub tuam txhab Beier siv enzyme-linked immunosorbent assay (ELISA) thiab colloidal kub txoj kev los tsim Enterovirus 71 Antibody Test Kits thiab Coxsackievirus A16 IgM Antibody Test Kits rau qhov sib txawv ntawm kev kuaj HFMD kab mob. Serum antibody detection muaj siab rhiab heev, zoo tshwj xeeb, thiab yog yooj yim, ceev, thiab haum rau kev soj ntsuam kuaj nyob rau hauv cov tsev kho mob nyob rau hauv tag nrho cov theem thiab rau loj-scale soj ntsuam kab mob.
Cov ntsuas ntsuas tshwj xeeb thiab qhov tseem ceeb ntawm kev kuaj mob ntawm EV71 Kab Mob
Kev kuaj mob tshwj xeeb ntawm EV71 yog nyob ntawm kev tshawb pom ntawm EV71-RNA, EV71-IgM, thiab EV71-IgG cov tshuaj tiv thaiv kab mob hauv cov ntshav, lossis kuaj pom ntawm EV71-RNA hauv cov qauv swab.
Tom qab tus kab mob EV71, IgM cov tshuaj tiv thaiv tshwm sim thawj zaug, nce siab hauv lub lim tiam thib ob. IgG cov tshuaj tiv thaiv pib tshwm sim nyob rau lub lim tiam thib ob tom qab kis kab mob thiab txuas ntxiv mus ntev. EV71-IgM yog qhov taw qhia tseem ceeb ntawm tus kab mob thawj zaug lossis tsis ntev los no, ua kom yooj yim rau kev kuaj pom thiab kho tus kab mob EV71. EV71-IgG yog qhov taw qhia tseem ceeb rau kev kuaj mob sib txawv ntawm kev kis tus kab mob, muaj txiaj ntsig zoo rau kev tshawb nrhiav kab mob sib kis thiab kev ntsuam xyuas kev siv tshuaj tiv thaiv. Txheeb xyuas qhov kev hloov pauv ntawm cov tshuaj tiv thaiv kab mob sib kis ntawm cov kab mob sib kis thiab cov kab mob convalescent tuaj yeem txiav txim siab tus kab mob EV71; Piv txwv li, plaub-fold lossis ntau dua geometric nce hauv cov tshuaj tiv thaiv kab mob titer hauv cov ntshav qab zib convalescent piv rau cov ntshav qab zib tuaj yeem raug txiav txim raws li tus kab mob EV71 tam sim no.
Cov Kev Ntsuas Tshwj Xeeb thiab Kev Kho Mob Tseem Ceeb ntawm CA16 Kab Mob
Qhov kev kuaj mob tshwj xeeb ntawm CA16 tus kab mob yog nyob ntawm kev tshawb pom ntawm CA16-RNA, CA16-IgM, thiab CA16-IgG cov tshuaj tiv thaiv hauv cov ntshav, lossis kuaj pom ntawm CA16-RNA hauv cov qauv swab.
Tom qab tus kab mob CA16, IgM cov tshuaj tiv thaiv tshwm sim thawj zaug, nce siab hauv lub lim tiam thib ob. IgG cov tshuaj tiv thaiv pib tshwm sim nyob rau lub lim tiam thib ob tom qab kis kab mob thiab txuas ntxiv mus ntev. CA16-IgM yog qhov taw qhia tseem ceeb ntawm tus kab mob thawj zaug lossis tsis ntev los no.
Qhov tseem ceeb ntawm Combined EV71 thiab CA16 Antibody Test
HFMD yog tshwm sim los ntawm ntau tus kab mob enteroviruses, nrog rau cov serotypes yog EV71 thiab CA16. Kev tshawb fawb qhia tias HFMD tshwm sim los ntawm tus kab mob CA16 feem ntau tshwm sim nrog cov tsos mob zoo li qub, muaj teeb meem tsawg dua, thiab muaj qhov tshwm sim zoo. Hauv qhov sib piv, HFMD tshwm sim los ntawm EV71 feem ntau tshwm sim nrog cov tsos mob hnyav dua, muaj tus nqi siab dua ntawm cov neeg mob hnyav thiab cov neeg mob tuag, thiab feem ntau cuam tshuam nrog cov teeb meem hauv lub paj hlwb. Cov tsos mob ntawm HFMD yog qhov nyuaj thiab feem ntau tsis muaj qhov xwm txheej, ua rau kev kuaj mob tshwj xeeb nyuaj, tshwj xeeb tshaj yog nyob rau theem pib. Qhov tseem ceeb ntawm kev sim tshuaj tiv thaiv kab mob sib xyaw ua ke yog nyob rau hauv kev hloov lub sijhawm siv sijhawm thiab cumbersome cov txheej txheem cais tus kab mob, txheeb xyuas cov kab mob serologically, thiab muab lub hauv paus rau kev kuaj mob, cov tswv yim kho mob, thiab kev kuaj kab mob.
Product Performance Analysis
EV71-IgM ELISAKitKev Ntsuam Xyuas Kev Ua Haujlwm
| Stxaus | No. ntawmCov ntaub ntawv | EV71-IgM zoo | EV71- IbM Tsis zoo | Skev xav | Specificity |
| Pom zoo EV71 Cases | 302 | 298 | 4 | 98.7% | —– |
| Cov Kab Mob Tsis-EV71 | 25 | 1 | 24 | —– | 96% |
| Cov pejxeem | 700 | —– | 700 | —– | 100% |
Cov txiaj ntsig qhia tias:Beier EV71-IgM Test Kit qhia tau hais tias muaj kev nkag siab zoo thiab qhov tshwj xeeb zoo rau kev kuaj ntshav los ntawm cov neeg mob EV71. Cov ntaub ntawv qhov chaw: National Institute for Viral Disease Control and Prevention, Suav CDC.
EV71-IgG ELISA Kit Performance Analysis (I)
| Stxaus | No. ntawmCov ntaub ntawv | EV71-IgG Positive | EV71- IbG Negative | Skev xav | Specificity |
| Pom zoo EV71 Cases | 310 | 307 | 3 | 99.0% | —– |
| Cov Kab Mob Tsis-EV71 | 38 | 0 | 38 | —– | 100% |
| Cov pejxeem | 700 | 328 | 372 ib | —– | 100% |
EV71-IgG ELISA Kit Performance Analysis (II)
| Stxaus | No. ntawmCov ntaub ntawv | EV71-IgG Positive | EV71- IbG Negative | Skev xav | Specificity |
| General Population, Neutralization Test Positive | 332 | 328 | 4 | 98.8% | —– |
| General Population, Neutralization Test Negative | 368 | —– | 368 | —– | 100% |
Cov txiaj ntsig qhia tias:Beier EV71-IgG Test Kit qhia tau tias muaj txiaj ntsig zoo rau cov ntshav los ntawm cov tib neeg uas muaj tus kab mob EV71 rov tshwm sim. Cov ntaub ntawv qhov chaw: National Institute for Viral Disease Control and Prevention, Suav CDC.
CA16-IgM ELISA Kit Performance Analysis
| Stxaus | No. ntawmCov ntaub ntawv | CA16-IgM Positive | CA 16-IgM Tsis zoo | Skev xav | Specificity |
| Pom zoo CA16 Cases | 350 | 336 | 14 | 96.0% | —– |
| Cov pejxeem | 659 ib | 0 | 659 ib | —– | 100% |
Cov txiaj ntsig qhia tias:Beier CA16-IgM Test Kit ua kom pom qhov ntsuas siab thiab muaj kev sib raug zoo. Cov ntaub ntawv qhov chaw: National Institute for Viral Disease Control and Prevention, Suav CDC.
EV71-IgM Test Kit (Colloidal Kub) Kev Ntsuam Xyuas Kev Ua Haujlwm
| Stxaus | No. ntawmCov ntaub ntawv | EV71-IgM zoo | EV71- IbM Tsis zoo | Skev xav | Specificity |
| EV71-IgM Cov Qauv Zoo | 90 | 88 | 2 | 97.8% | —– |
| PCR Positive Samples / Non-HFMD Cases | 217 | 7 | 210 | —– | 96.8% |
Cov txiaj ntsig qhia tias:Beier EV71-IgM Test Kit (Colloidal Gold) qhia tau hais tias muaj kev nkag siab zoo thiab qhov tshwj xeeb zoo rau kev kuaj ntshav los ntawm cov neeg muaj kab mob EV71. Cov ntaub ntawv qhov chaw: National Institute for Viral Disease Control and Prevention, Suav CDC.
CA16-IgM Test Kit (Colloidal Kub) Kev Ntsuam Xyuas Kev Ua Haujlwm
| Stxaus | No. ntawmCov ntaub ntawv | CA16-IgM Positive | CA 16-IgM Tsis zoo | Skev xav | Specificity |
| CA16-IgM Cov Qauv Zoo | 248 | 243 | 5 | 98.0% | —– |
| PCR Cov Qauv Zoo / Tsis yog HFMD Cases | 325 | 11 | 314 | —– | 96.6% |
Cov txiaj ntsig qhia tias:Beier CA16-IgM Test Kit (Colloidal Gold) qhia tau hais tias muaj kev nkag siab zoo thiab qhov tshwj xeeb zoo rau kev kuaj ntshav los ntawm cov neeg muaj CA16. Cov ntaub ntawv qhov chaw: National Institute for Viral Disease Control and Prevention, Suav CDC.
Post lub sij hawm: Oct-30-2025